Write For Us

Genetic sequencing helps scientists mine soil for antibiotics


 Thousands of unknown microbes living in the soil, and scientists think some of them likely produce molecules with antibiotic and antifungal qualities. Photo by Zosia Rostomian/Berkeley Lab

By Brooks Hays, UPI

Scientists have developed a more efficient way to search for potential antibiotics living in the soil.

The new method, called metagenomic sequencing, allows scientists to sequence the genomes of multiple microbes living in a small soil sample.

Scientists can use the survey method to identify gene sequences related to the production of molecules with antibiotic or antifungal qualities -- defense mechanisms evolved by microbes that could also help humans battle infections.

Many studies show problematic bacteria, including MRSA, E. coli and others, are becoming increasingly resistant to common antibiotics.

To test the new genome sequencing method, scientists collected 60 10-gram samples of dirt from a few inches beneath the surface of a Northern California meadow. Researchers used metagenomic sequencing to identify the genomes of 1,000 different microbes, 360 of which were found to be new species.

"Soil is the last frontier from the perspective of genome-resolved metagenomics," Jill Banfield, a professor at the University of California, Berkeley's Innovative Genomics Institute, said in a news release. "It is just full of many, many, many different types of organisms, a lot of them closely related and present in fairly low abundances, so it is hard to tease them apart."

Scientists are currently analyzing the newly sequenced genomes, searching for gene sequences related to the production of unique and complex molecules. These genes can be inserted into other organisms to see if they do indeed code for the production of a potentially useful protein or enzyme.

These proteins and enzymes could yield molecules with a variety of medicinal qualities.

"Most of these new biosynthetic molecules are coming out of what people know to be the most abundant bacteria in soil, they just hadn't been found because people didn't have genomes for them," Banfield said. "We expect to find novel antibiotics, which could help humanity, but also novel pharmaceuticals more broadly."

Researchers detailed their new sequencing technology this week in the journal Nature.


Note: If you think this story need more information or correction, feel free to comment below your opinion and reaction.
Like & Follow to Stay Updated ...


AI,3,Amazon,1,Apple,5,Emoji,1,Facebook,17,Games,35,Google,7,Instagram,6,Science,205,Security,4,Social Media,24,Tech,242,Technology,1396,Tesla,5,Twitter,4,
Technology - U.S. Daily News: Genetic sequencing helps scientists mine soil for antibiotics
Genetic sequencing helps scientists mine soil for antibiotics
Technology - U.S. Daily News
Loaded All Posts Not found any posts VIEW ALL Read More Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS PREMIUM CONTENT IS LOCKED STEP 1: Share. STEP 2: Click the link you shared to unlock Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy